Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma
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چکیده
منابع مشابه
Kynurenic acid and schizophrenia.
In recent years the "dopamine (DA) hypothesis of schizophrenia", has been modified into a more diversified view where an attenuated glutamatergic neurotransmission is believed to participate in the pathogenesis of the disease. Thus, schizophrenia may be regarded as a glutamate deficiency disorder. Kynurenic acid (KYNA) is an endogenous glutamate antagonist with a preferential action at the glyc...
متن کاملAmino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro
The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor at endogenous brain concentrations. Recent studies have suggested that increase of brain KYNA levels is involved in psychiatric disorders such as schizophrenia and depression. KYNA-producing enzymes have broad substrate specificity for amino acids, and brain uptake of kynure...
متن کاملCarotid surgery affects plasma kynurenic acid concentration: A pilot study
BACKGROUND An increase in plasma kynurenic acid (KYNA) concentration has been observed following surgery, inflammation, and cerebral pathologies. The aim of the present study was to analyze the changes in plasma KYNA concentration in patients undergoing carotid surgery (CS). MATERIAL AND METHODS Adult patients undergoing elective carotid endarterectomy (CEA) or carotid angioplasty with stent ...
متن کاملEffect of ellagic acid on thiol levels in different brain tissue in an animal model of Parkinson's disease
Background & Aim: Parkinson's disease (PD) can be created with loss of dopaminergic substantial nigra neurons which is widely associated with oxidative stress and reduced glutathione (GSH), as the most important and abundant thiol in tissues and one of the antioxidant defense, is one of the earliest biochemical events related to Parkinson's and consumption of antioxidants has a protective effec...
متن کاملEffect of ellagic acid on thiol levels in different brain tissue in an animal model of Parkinson's disease
Background & Aim: Parkinson's disease (PD) can be created with loss of dopaminergic substantial nigra neurons which is widely associated with oxidative stress and reduced glutathione (GSH), as the most important and abundant thiol in tissues and one of the antioxidant defense, is one of the earliest biochemical events related to Parkinson's and consumption of antioxidants has a protective effec...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2021
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2021.e06124